Which category is characterized by an accepted medical use with high risk for abuse and severe dependence?

The category characterized by an accepted medical use with a high risk for abuse and severe dependence is Schedule II (CII). Medications classified under this schedule have a recognized therapeutic benefit but also possess the potential for significant physical or psychological dependence due to their potency and addictive properties. Examples of Schedule II substances include opioids like oxycodone and narcotics such as morphine, both of which, while effective for pain management, are strictly regulated because of their potential for misuse.

In contrast, the other categories have different characteristics regarding their accepted medical uses, potential for abuse, and levels of dependence. Schedule I (CI) substances are those with no accepted medical use and a high potential for abuse, making them illegal to prescribe. Schedule III (CIII) substances are generally associated with lower potential for abuse and dependence compared to Schedule II substances, and Schedule IV (CIV) substances have an even lower risk, often leading to less stringent regulations. This distinction highlights the rigorous control measures surrounding Schedule II medications due to their potential risks.