What is the direction of HEPA filtration in hazardous compounding?

In hazardous compounding, the direction of HEPA filtration is critical for maintaining a safe environment for both the compounding professionals and the integrity of the compounded products. HEPA filters are designed to capture particles and contaminants from the air, including hazardous drug substances. The top/down airflow allows clean, filtered air to flow down over the compounding area, creating a protective barrier. This downward airflow pattern ensures that any potentially harmful or airborne contaminants are pushed away from the compounding personnel and product, rather than circulating back into their space. This helps to minimize exposure to hazardous materials while also maintaining sterility and preventing contamination of the compounded drugs.

Understanding the airflow direction in sterile compounding environments is essential for compliance with safety protocols and regulations regarding hazardous drugs, as mandated by organizations such as the USP and local health authorities.