What is the beyond-use date (BUD) for multi-dose vials?

The beyond-use date (BUD) for multi-dose vials is established to ensure the safety and efficacy of the medication throughout its use. Under the United States Pharmacopeia (USP) guidelines, multi-dose vials, once opened, generally have a BUD of 28 days, provided they are stored properly and have not been contaminated.

This 28-day time frame allows for the medication to be used multiple times but acknowledges that stability may decline after this period due to the potential for contamination or degradation. After 28 days, the risk of bacterial growth or deterioration increases, which could compromise patient safety.

Options such as 14, 21, or 30 days do not align with the established standards for multi-dose vials as specified in pharmacy guidelines, making the choice of 28 days the correct answer in this context.