What delivery method is associated with "controlled release" in pharmaceuticals?

The term "controlled release" in pharmaceuticals refers to a delivery method where the drug is released over an extended period of time, rather than being released all at once. This approach is designed to maintain therapeutic drug levels in the bloodstream for longer durations, improving efficacy and minimizing side effects.

Controlled release formulations allow for a more gradual absorption of the medication, which can help maintain consistent drug levels and potentially enhance patient adherence to therapy. This contrasts with immediate release formulations, where the drug is released quickly, often leading to a spike in drug concentration and then a rapid decline. Similarly, delayed release refers to formulations that do not release the drug immediately but could still result in rapid absorption once the release occurs. Bioequivalence pertains to the comparison between drug products, ensuring they have similar bioavailability but does not describe the release mechanism directly.

Thus, the association of "controlled release" with release over time captures the essence of how these formulations are designed to operate, making it the correct choice.